Article

Discovery and characterization of novel inhibitors against ALS-related SOD1(A4V) aggregation through screening of a chemical library using Differerential Scanning Fluorimetry (DSF)

2023-12-21

Abstract excerpt

<h4>ABSTRACT</h4> Cu/Zn Superoxide Dismutase 1 (SOD1) is a 32-kDa cytosolic dimeric metalloenzyme that neutralizes superoxide anions into harmless oxygen and hydrogen peroxide. Mutations in SOD1 are associated with ALS, a disease causing motor neuron atrophy and subsequent mortality. These mutations exert their harmful effects through a gain of function mechanism, rather than loss of function. Despite extensive r...

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Literature Corpus work: e0297267-5f4f-523a-8d0e-c34b6f868ce2
DOI: 10.1101/2023.12.20.572618

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