Article

Germline variants associated with alternative splicing in colonic mucosa

2020-01-01

Abstract excerpt

The heritability of colorectal cancer (CRC) has been estimated between 7.4% and 26% from a range of analyses based on family lineages and genetic similarity. Certain rare, high penetrance variants are well characterized, though these are estimated to account for only ~5% of all CRC cases. The majority of GWASidentified risk SNPs for CRC fall within non-coding regions, and the mechanisms by which the majority of th...

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Literature Corpus work: b8e7f07a-87f8-5b7c-a94e-28de2e9e20ab
DOI: 10.7488/era/276

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