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Article

Novel insights into genetic susceptibility for colorectal cancer from transcriptome-wide association and functional investigation.

Journal of the National Cancer Institute - 10 Jan 2024

Chen Zhishan, Song Wenqiang, Shu Xiao-Ou, Wen Wanqing, Devall Matthew, Dampier Christopher, Moratalla-Navarro Ferran, Cai Qiuyin, Long Jirong, Van Kaer Luc, Wu Lan, Huyghe Jeroen R, Thomas Minta, Hsu Li, Woods Michael O, Albanes Demetrius, Buchanan Daniel D, Gsur Andrea, Hoffmeister Michael, Vodicka Pavel, Wolk Alicja, Marchand Loic Le, Wu Anna H, Phipps Amanda I, Moreno Victor, Ulrike Peters, Zheng Wei, Casey Graham, Guo Xingyi

Abstract excerpt

BACKGROUND: Transcriptome-wide association studies have been successful in identifying candidate susceptibility genes for colorectal cancer (CRC). To strengthen susceptibility gene discovery, we conducted a large transcriptome-wide association study and an alternative splicing transcriptome-wide association study in CRC using improved genetic prediction models and performed in-depth functional investigations....

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Identifiers

PMID: 37632791
DOI: 10.1093/jnci/djad178
PMCID: PMC10777674

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