Article

Tumor heterogeneity and prognostic impact of the aberrant splicing burden of colorectal cancers

2023-06-01

Abstract excerpt

<title>Abstract</title> <p>The colorectal cancer (CRC) transcriptome has important clinicopathological associations. Alternative splicing is a major determinant of transcriptomic complexity, but the impact of aberrant splicing on tumor heterogeneity and patient outcome from CRC is not well described. We investigated inter- and intra-tumor splicing heterogeneity among 504 primary tumor samples and 42 non-malignant...

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Literature Corpus work: ba777915-fb3c-5b7f-ae46-c92b7114b8d7
DOI: 10.21203/rs.3.rs-2928509/v1

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