Article
Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes.
Nature communications - 30 May 2025
Hazelwood Emma, Canson Daffodil M, Deslandes Benedita, Wang Xuemin, Kho Pik Fang, Legge Danny, Constantinescu Andrei-Emil, Lee Matthew A, Bishop D Timothy, Chan Andrew T, Gruber Stephen B, Hampe Jochen, Le Marchand Loic, Woods Michael O, Pai Rish K, Schmit Stephanie L, Figueiredo Jane C, Zheng Wei, Huyghe Jeroen R, Murphy Neil, Gunter Marc J, Richardson Tom G, Whitehall Vicki L J, Vincent Emma E, Glubb Dylan M, O'Mara Tracy A
Abstract excerpt
Genome-wide association studies have suggested numerous colorectal cancer (CRC) susceptibility genes, but their causality and therapeutic potential remain unclear. To prioritise causal associations between gene expression/splicing and CRC risk (52,775 cases; 45,940 controls), we perform a transcriptome-wide association study (TWAS) across six tissues with Mendelian randomisation and colocalisation, integrating...
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