Article

Downregulation of <i>Let-7</i> miRNA promotes Tc17 differentiation and emphysema via de-repression of RORγt

2023-10-16

Abstract excerpt

<h4>ABSTRACT</h4> Environmental air irritants including nanosized carbon black (nCB) can drive systemic inflammation, promoting chronic obstructive pulmonary disease (COPD) and emphysema development. The let-7 family of miRNAs is associated with IL-17-driven T cell inflammation, a canonical signature of lung inflammation. Recent evidence suggests the let-7 family is downregulated in patients with COPD, however,...

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Literature Corpus work: b8d712cc-c2fe-5e05-85e6-8dfb74234f82
DOI: 10.1101/2023.10.12.562059

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