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Article

Impaired lnc-IL7R modulatory mechanism of Toll-like receptors is associated with an exacerbator phenotype of chronic obstructive pulmonary disease.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2020

Wu Sheng-Ming, Feng Po-Hao, Chuang Hsiao-Chi, Ho Shu-Chuan, Fan Chung Kian, Chen Kuan-Yuan, Wu Guang-Sing, Chen Tzu-Tao, Tseng Chien-Hua, Liu Wen-Te, Lee Kang-Yun

Abstract excerpt

Patients with chronic obstructive pulmonary disease (COPD) are susceptible to bacterial infections, which worsen lung inflammation and contribute to lung function decline and acute exacerbation. Long noncoding (lnc) RNAs are emerging regulators of inflammation with unknown clinical relevance. Herein, we report that levels of the Toll-like receptor (TLR)-related lnc interleukin (IL) 7 receptor (IL7R) were...

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Share to Acetylation
Share to Alveolar Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interleukin-7 Receptor alpha Subunit

Share to Macrophages, Alveolar

Share to Pulmonary Disease, Chronic Obstructive

Share to RNA, Long Noncoding

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Source

Identifiers

PMID: 32780913
DOI: 10.1096/fj.202000632R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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