Back to search

Article

Cross-species graph-embedding unmasks the ageing microenvironment as a key determinant of pancreatic cancer malignant cell biology and therapy response

2026-02-03

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis and is characterised by an extensive pro-tumorigenic stroma. Although most PDAC cases occur in older patients, the impact of ageing on malignant-stromal interactions and therapy response remains poorly understood. Here, we established orthotopically-grafted organoid-derived PDAC models across three murine age groups to characterise changes in the PDAC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3a367e7d-12f6-5cda-b1aa-e9f60569fd2c
DOI
10.64898/2026.02.02.703350
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Cross-species graph-embedding unmasks the ageing microenvironment as a key determinant of pancreatic cancer malignant cell biology and therapy responseDOI 10.64898/2026.02.02.703350
Cross-species single-cell atlases chart progression, therapy-driven remodelling and immune evasion in pancreatic cancerSemantic proximity
The Aging Microenvironment as a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic CancerSemantic proximity
Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinomaSemantic proximity
Multicellular Modelling of Difficult-to-Treat Gastrointestinal Cancers: Current Possibilities and ChallengesSemantic proximity
Assays for orthotopic PDAC mouse modelsSemantic proximity
Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolutionSemantic proximity
The Diverse Applications of Pancreatic Ductal Adenocarcinoma OrganoidsSemantic proximity
Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolutionSemantic proximity
Cross-species analysis identifies genotype-driven vulnerabilities in lung adenocarcinomaSemantic proximity
Tumor heterogeneity: An oncogenic driver of PDAC progression and therapy resistance under stress conditions.Semantic proximity
Convergence for Inactivation of TGFβ Signaling Is a Common Feature of Advanced Pancreatic Cancer.Semantic proximity
Genomic Landscape of Pancreatic Adenocarcinoma in Younger versus Older Patients: Does Age Matter?Semantic proximity
Select a neighboring publication to make it the new centre.