Article

Multi-omics integration of malignant peripheral nerve sheath tumors identifies potential targets based on chromosome 8q status

2026-01-27

Abstract excerpt

<h4>Background</h4> Chromosome 8q (chr8q) copy number gain is associated with high-grade transformation in malignant peripheral nerve sheath tumors (MPNST), an aggressive soft tissue tumor with poor outcomes in the high-risk and metastatic settings. Although chr8q gain is associated with inferior overall survival in patients with MPNST, standard of care therapies do not currently consider stratification by genomi...

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Literature Corpus work: b8b562c2-dd82-5729-8423-9df46cd0aacb
DOI: 10.64898/2026.01.26.701599

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