Article
Ex vivo to in vivo model of malignant peripheral nerve sheath tumors for precision oncology.
Neuro-oncology - 2 Nov 2023
Larsson Alex T, Bhatia Himanshi, Calizo Ana, Pollard Kai, Zhang Xiaochun, Conniff Eric, Tibbitts Justin F, Rono Elizabeth, Cummins Katherine, Osum Sara H, Williams Kyle B, Crampton Alexandra L, Jubenville Tyler, Schefer Daniel, Yang Kuangying, Lyu Yang, Pino James C, Bade Jessica, Gross John M, Lisok Alla, Dehner Carina A, Chrisinger John S A, He Kevin, Gosline Sara J C, Pratilas Christine A, Largaespada David A, Wood David K, Hirbe Angela C
Abstract excerpt
BACKGROUND: Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas that often develop in patients with neurofibromatosis type 1 (NF1). To address the critical need for novel therapeutics in MPNST, we aimed to establish an ex vivo 3D platform that accurately captured the genomic diversity of MPNST and could be utilized in a medium-throughput manner for drug screening studies to be...
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