Article

Multi-omics integration of malignant peripheral nerve sheath tumors nominates therapies based on chromosome 8q status

2026-04-28

Abstract excerpt

<title>Abstract</title> Chromosome 8q (chr8q) copy number gain is associated with high-grade transformation in malignant peripheral nerve sheath tumors (MPNST), an aggressive soft tissue sarcoma. To identify potential treatments for patients with chr8q gain, we leveraged our library of MPNST patient-derived xenografts (PDX) and collected global proteomics and phosphoproteomics measurements for six of these m...

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Literature Corpus work: b411dbaa-64fa-593a-8fb0-e5b694031ac6
DOI: 10.21203/rs.3.rs-9097791/v1

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