Article

Chromosome 8 gain is associated with high-grade transformation in MPNST

2020-12-07

Abstract excerpt

One of the most common malignancies affecting adults with Neurofibromatosis type 1 (NF1) is the malignant peripheral nerve sheath tumor (MPNST), an aggressive and often fatal sarcoma which commonly arises from benign plexiform neurofibromas. Despite advances in our understanding of MPNST pathobiology, there are few effective therapeutic options, and no investigational agents have proven success in clinical trials....

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Literature Corpus work: 66c84190-10d4-52fd-b59c-47497889cd73
DOI: 10.1101/2020.12.04.20242818

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