Article

Single cell landscape of hypertrophic scars identifies serine proteases as key regulators of myofibroblast differentiation

2020-06-18

Abstract excerpt

Despite recent advances in understanding skin scarring, mechanisms triggering hypertrophic scar formation are still poorly understood. In the present study we performed single-cell sequencing of mature human hypertrophic scars and developing scars in mice. Compared to normal skin, we found significant differences in gene expression in most cell types present in scar tissue. Fibroblasts (FBs) showed the most promin...

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Literature Corpus work: 5b0557e6-fc62-5676-b240-f63c1eb0663f
DOI: 10.1101/2020.06.17.157073

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