Article
Bioactive tetrapeptide GEKG boosts extracellular matrix formation: <i>in vitro</i> and <i>in vivo</i> molecular and clinical proof
22 Jun 2011
Abstract excerpt
The 'matrikine' concept claims that processing of the precursors for collagen results in the formation of peptides such as KTTKS which in turn augments extracellular matrix (ECM) production. In the present study, we show the development of an anti-ageing active from an in silico approach by molecular design resulting in the tetrapeptide GEKG derived from ECM proteins. The efficacy of the peptide to significantly...
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