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Machine learning analysis of gene expression reveals TP53 Mutant-like AML with wild type TP53 and poor prognosis

14 May 2024

Abstract excerpt

TP53 mutations ( TP53Mut ) define the most rapidly fatal AML subtype [ 1 , 2 ] (Supplementary Fig. S1A ). We used AML datasets (Beat AML and TCGA LAML [ 3 , 4 , 5 , 6 ] (Supplementary Tables S1 – 3 ), to define the gene expression profile (GEP) of TP53Mut AML. The diagnostic, relapsed, and refractory TP53Mut cases in Beat AML were transcriptionally similar to those in the TCGA (which includes only diagnostic...

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PMID: 38744822
DOI: 10.1038/s41408-024-01061-3

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