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Single-cell RNA sequencing reveals special basal cells and fibroblasts in idiopathic pulmonary fibrosis

9 Jul 2024

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is the most predominant type of idiopathic interstitial pneumonia and has an increasing incidence, poor prognosis, and unclear pathogenesis. In order to investigate the molecular mechanisms underlying IPF further, we performed single-cell RNA sequencing analysis on three healthy controls and five IPF lung tissue samples. The results revealed a significant shift in epithelial...

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PMID: 38982264
DOI: 10.1038/s41598-024-66947-5

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