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Article

Dysregulated Cell–Cell Communication Characterizes Pulmonary Fibrosis

21 Oct 2022

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a progressive disease of older adults characterized by fibrotic replacement of functional gas exchange units in the lung. The strongest risk factor for IPF is a genetic variantin the promoter region of the gel-forming mucin, MUC5B. To better understand how the MUC5B variant influences development of fibrosis, we used the NicheNet R package and leveraged publicly available...

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PMID: 36291184
DOI: 10.3390/cells11203319

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