Article

Long-term Reconstruction of Human Airway Epithelium-like Structure <i>in Vivo</i> with hESCs-derived organoid cells

2020-07-18

Abstract excerpt

Human embryonic stem cells (hESCs) derived lung organoids (HLOs) provide a promising model to study human lung development and disease. However, whether HLO cells could reconstitute airway epithelial structure in vivo remains unclear. Here we established an orthotopic xenograft system for hESCs-derived HLOs, enabling stable reconstruction of human airway epithelium in vivo . Removal of the mouse airway epitheliu...

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Literature Corpus work: b88129cc-e64f-5725-86f7-4820a92ed10c
DOI: 10.1101/2020.07.18.209940

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