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Generation of 3D lung organoids from human induced pluripotent stem cells for modeling of lung development and viral infection

29 Aug 2023

Abstract excerpt

models has hampered progress in understanding human lung development and disease. Here, we describe a protocol in which human induced pluripotent stem cells (hiPSCs) undergo stepwise differentiation into definitive endoderm (>88% population) to three-dimensional (3D) lung organoids (LORGs), which contain both epithelial and mesenchymal cellular architecture and display proximal and distal airway patterning. These...

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PMID: 37809493
DOI: 10.1016/j.heliyon.2023.e19601

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