Article

Identifying modifiable comorbidities of schizophrenia by integrating electronic health records and polygenic risk

2023-06-05

Abstract excerpt

Patients with schizophrenia have substantial comorbidity contributing to reduced life expectancy of 10-20 years. Identifying which comorbidities might be modifiable could improve rates of premature mortality in this population. We hypothesize that conditions that frequently co-occur but lack shared genetic risk with schizophrenia are more likely to be products of treatment, behavior, or environmental factors and t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7f6b19c1-e585-5d8d-a1bd-e8beb26627e0
DOI: 10.1101/2023.06.01.23290057

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identifying modifiable comorbidities of schizophrenia by integrating electronic health records and polygenic riskDOI 10.1101/2023.06.01.23290057Read

Novel disease associations with schizophrenia genetic risk revealed in ~400,000 UK Biobank participants.Semantic proximity Read

Penetrance and pleiotropy of polygenic risk scores for schizophrenia in 106,160 patients across four healthcare systemsSemantic proximity Read

Schizophrenia and co-morbidity risk: Evidence from a data driven phenomewide association study.Semantic proximity Read

Genetic liability to physical health conditions influences comorbidities in individuals with severe mental illnessSemantic proximity Read

Disorder-specific and shared genetic architecture underlying schizophrenia and bipolar disorderSemantic proximity Read

Genetic correlates of medical comorbidity associated with schizophrenia and treatment with antipsychotics.Semantic proximity Read

A global overview of genetically interpretable comorbidities among common diseases in UK BiobankSemantic proximity Read

Multimorbidity landscape of schizophrenia: Insights from meta-analysis of genome wide association studies.Semantic proximity Read

Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression in the VA Health Care SystemSemantic proximity Read

Polygenic risk of psychiatric disorders exhibits cross-trait associations in electronic health record dataSemantic proximity Read

Schizophrenia, "just the facts" what we know in 2008. 2. Epidemiology and etiology.Semantic proximity Read

Genetic Relationship between Schizophrenia and Nicotine Dependence.Semantic proximity Read