Back to search

Article

A Genetic Screen Links the Disease-Associated Nab2 RNA-Binding Protein to the Planar Cell Polarity Pathway in <i>Drosophila melanogaster</i>

2019-12-23

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the gene encoding the ubiquitously expressed RNA-binding protein ZC3H14 result in a non-syndromic form of autosomal recessive intellectual disability. Studies in Drosophila have defined roles for the ZC3H14 ortholog, Nab2 (aka Drosophila Nab2 or dNab2), in axon guidance and memory due in part to interaction with a second RNA-binding protein, the fly Fragile X homolog Fmr1, and cor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b85f1ae1-9415-5d6d-a478-148054e3b348
DOI
10.1101/2019.12.23.887257
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Genetic Screen Links the Disease-Associated Nab2 RNA-Binding Protein to the Planar Cell Polarity Pathway in <i>Drosophila melanogaster</i>DOI 10.1101/2019.12.23.887257
The RNA binding protein Nab2 regulates the proteome of the developing <i>Drosophila</i> brainSemantic proximity
The polyadenosine RNA binding protein Nab2 regulates alternative splicing and intron retention during <i>Drosophila melanogaster</i> brain developmentSemantic proximity
The Disease-Associated Proteins <i>Drosophila</i> Nab2 and Ataxin-2 Interact with Shared RNAs and Coregulate Neuronal MorphologySemantic proximity
The Nab2 RNA binding protein promotes sex-specific splicing of <i>Sex lethal</i> in <i>Drosophila</i> neuronal tissueSemantic proximity
The RNA binding protein Nab2 regulates splicing of the RhoGEF <i>trio</i> transcript to govern axon and dendrite morphologySemantic proximity
New kid on the ID block: neural functions of the Nab2/ZC3H14 class of Cys₃His tandem zinc-finger polyadenosine RNA binding proteins.Semantic proximity
Axon development is regulated at genetic and proteomic interfaces between the integrin adhesome and the RPM-1 ubiquitin ligase signaling hubSemantic proximity
The RNA binding protein Nab2 genetically interacts with multiple RNA exosome cofactors to regulate target RNAsSemantic proximity
Drosophila NAB (dNAB) is an orphan transcriptional co-repressor required for correct CNS and eye development.Semantic proximity
Genetic interaction screen for severe neurodevelopmental disorders reveals a functional link between Ube3a and Mef2 in Drosophila melanogaster.Semantic proximity
Patient-associated mutations in <i>Drosophila</i> Alk perturb neuronal differentiation and promote survivalSemantic proximity
Ankle2, A Target of Zika Virus, Controls Asymmetric Cell Division of Neuroblasts and Uncovers a Novel Microcephaly PathwaySemantic proximity
Select a neighboring publication to make it the new centre.