Article

The RNA binding protein Nab2 regulates the proteome of the developing <i>Drosophila</i> brain

2020-12-11

Abstract excerpt

The human ZC3H14 gene, which encodes a ubiquitously expressed polyadenosine zinc finger RNA binding protein, is mutated in an inherited form of autosomal recessive, non-syndromic intellectual disability. To gain insight into ZC3H14 neurological functions, we previously developed a Drosophila melanogaster model of ZC3H14 loss by deleting the fly ortholog, Nab2. Studies in this invertebrate model reveal that Nab2...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8267c857-02fa-5806-98b5-bb3cada3ad91
DOI: 10.1101/2020.12.10.419846

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The RNA binding protein Nab2 regulates the proteome of the developing <i>Drosophila</i> brainDOI 10.1101/2020.12.10.419846Read

A Genetic Screen Links the Disease-Associated Nab2 RNA-Binding Protein to the Planar Cell Polarity Pathway in <i>Drosophila melanogaster</i>Semantic proximity Read

The Disease-Associated Proteins <i>Drosophila</i> Nab2 and Ataxin-2 Interact with Shared RNAs and Coregulate Neuronal MorphologySemantic proximity Read

New kid on the ID block: neural functions of the Nab2/ZC3H14 class of Cys₃His tandem zinc-finger polyadenosine RNA binding proteins.Semantic proximity Read

The polyadenosine RNA binding protein Nab2 regulates alternative splicing and intron retention during <i>Drosophila melanogaster</i> brain developmentSemantic proximity Read

The Nab2 RNA binding protein promotes sex-specific splicing of <i>Sex lethal</i> in <i>Drosophila</i> neuronal tissueSemantic proximity Read

Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans.Semantic proximity Read

ZNF423 orthologs are highly constrained in vertebrates but show domain-level plasticity across invertebrate lineagesSemantic proximity Read

The RNA binding protein Nab2 regulates splicing of the RhoGEF <i>trio</i> transcript to govern axon and dendrite morphologySemantic proximity Read

Loss of Zmiz1 in mice leads to impaired cortical development and autistic-like behaviorsSemantic proximity Read

Zeb2 DNA-binding sites in neuroprogenitor cells reveal autoregulation and affirm neurodevelopmental defects, including in Mowat-Wilson SyndromeSemantic proximity Read

Gradients of the Drosophila Chinmo BTB-zinc finger protein govern neuronal temporal identity.Semantic proximity Read

Biallelic missense variants in ZBTB11 can cause intellectual disability in humans.Semantic proximity Read