Drosophila NAB (dNAB) is an orphan transcriptional co-repressor required for correct CNS and eye development.

doi:10.1002/dvdy.10209

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Article

Drosophila NAB (dNAB) is an orphan transcriptional co-repressor required for correct CNS and eye development.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jan 2003

Clements Mark, Duncan Dianne, Milbrandt Jeffrey

Abstract excerpt

The mammalian NAB proteins have been identified previously as potent co-repressors of the EGR family of zinc finger transcription factors. Drosophila NAB (dNAB), like its mammalian counterparts, binds EGR1 and represses EGR1-mediated transcriptional activation from a synthetic promoter. In contrast, dNAB does not bind the Drosophila EGR-related protein klumpfuss. dnab RNA is expressed exclusively in a subset of...

Topics

Alleles
Amino Acid Sequence
Animals
Base Sequence
Central Nervous System
Cloning, Molecular
Crosses, Genetic
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Early Growth Response Protein 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Embryo, Nonmammalian

Gene Deletion

Humans

Immediate-Early Proteins

Models, Genetic

Molecular Sequence Data

Mutation

Source

Open in PubMed

Identifiers

PMID: 12508226
DOI: 10.1002/dvdy.10209

Genes

EGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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