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Drosophila Ca <sub>V</sub> 2 channels harboring human migraine mutations cause synapse hyperexcitability that can be suppressed by inhibition of a Ca <sup>2+</sup> store release pathway

2017-05-23

Abstract excerpt

<h4>ABSTRACT</h4> Gain-of-function mutations in the human Ca V 2.1 gene CACNA1A cause familial hemiplegic migraine type 1 (FHM1). To characterize cellular problems potentially triggered by Ca V 2.1 gains of function, we engineered mutations encoding FHM1 amino-acid substitutions S218L (SL) and R192Q (RQ) into transgenes of Drosophila melanogaster Ca V 2/ cacophony . We expressed the transgenes pan-neuronall...

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Literature Corpus work
b82cde85-1dd1-55e8-a0ce-dd73f0e3d6ed
DOI
10.1101/141366
Open publication

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Drosophila Ca <sub>V</sub> 2 channels harboring human migraine mutations cause synapse hyperexcitability that can be suppressed by inhibition of a Ca <sup>2+</sup> store release pathwayDOI 10.1101/141366
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