Article
Trigeminal ganglion neuron subtype-specific alterations of Ca(V)2.1 calcium current and excitability in a Cacna1a mouse model of migraine.
The Journal of physiology - 1 Dec 2011
Fioretti B, Catacuzzeno L, Sforna L, Gerke-Duncan M B, van den Maagdenberg A M J M, Franciolini F, Connor M, Pietrobon D
Abstract excerpt
Familial hemiplegic migraine type-1 (FHM1), a monogenic subtype of migraine with aura, is caused by gain-of-function mutations in Ca(V)2.1 (P/Q-type) calcium channels. The consequences of FHM1 mutations on the trigeminovascular pathway that generates migraine headache remain largely unexplored. Here we studied the calcium currents and excitability properties of two subpopulations of small-diameter trigeminal...
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