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Article

Trigeminal ganglion neuron subtype-specific alterations of Ca(V)2.1 calcium current and excitability in a Cacna1a mouse model of migraine.

The Journal of physiology - 1 Dec 2011

Fioretti B, Catacuzzeno L, Sforna L, Gerke-Duncan M B, van den Maagdenberg A M J M, Franciolini F, Connor M, Pietrobon D

Abstract excerpt

Familial hemiplegic migraine type-1 (FHM1), a monogenic subtype of migraine with aura, is caused by gain-of-function mutations in Ca(V)2.1 (P/Q-type) calcium channels. The consequences of FHM1 mutations on the trigeminovascular pathway that generates migraine headache remain largely unexplored. H...

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Identifiers

PMID: 22005682
DOI: 10.1113/jphysiol.2011.220533
PMCID: PMC3249056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22005682-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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