Article
Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons.
Proceedings of the National Academy of Sciences of the United States of America - 1 Oct 2002
Tottene Angelita, Fellin Tommaso, Pagnutti Stefano, Luvisetto Siro, Striessnig Joerg, Fletcher Colin, Pietrobon Daniela
Abstract excerpt
Insights into the pathogenesis of migraine with aura may be gained from a study of human Ca(V)2.1 channels containing mutations linked to familial hemiplegic migraine (FHM). Here, we extend the previous single-channel analysis to human Ca(V)2.1 channels containing mutation V1457L. This mutation increased the channel open probability by shifting its activation to more negative voltages and reduced both the unitary...
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