Article

Immune DNA signature of T-cell infiltration in breast tumor exomes

2016-04-08

Abstract excerpt

Tumor infiltrating lymphocytes (TILs) have been associated with favorable prognosis in multiple tumor types. The Cancer Genome Atlas (TCGA) represents the largest collection of cancer molecular data, but lacks detailed information about the immune environment. Here, we show that exome reads mapping to the complementarity-determining-region 3 (CDR3) of mature T-cell receptor beta ( TCRB ) can be used as an immune...

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Literature Corpus work: b81efa07-aca2-5078-a9d1-4bedf4af26d7
DOI: 10.1101/047753

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