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Article

Associations of TILs and genomic alterations in HER2+ early breast cancer.

Endocrine-related cancer - 1 Aug 2026

Lu Shuangshuang, Huang Jiahui, Gu Yijin, Wang Chaofu, Shen Kunwei, Fei Xiaochun, Chen Xiaosong

Abstract excerpt

This study investigated the associations between tumor-infiltrating lymphocytes (TILs), genomic features, and prognosis in HER2+ early breast cancer (EBC) patients receiving adjuvant trastuzumab. We retrospectively analyzed 864 HER2+ EBC patients from Shanghai Ruijin Hospital (2009-2017). The optimal threshold of TILs for predicting disease-free survival (DFS) and overall survival (OS) was explored. Whole-exome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42554712
DOI: 10.1530/ERC-25-0411

Genes

PIK3CA
BRCA2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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