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Tryptophan degradation by intestinal Bacteroides induces anti-tumor immunity and limits melanoma growth

2026-05-11

Abstract excerpt

Defining mechanisms used by gut microbiota to control anti-tumor immunity may offer novel therapeutic modalities. Here, we demonstrate that Bacteroides rodentium and closely related Bacteroides uniformis species induce anti-tumor immunity and limit melanoma development when colonized in either germ-free (GF) mice, mice with a complex microbiome, or WT mice. Enhanced CD8 + T cell infiltration seen in tumors of m...

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Identifiers and source

Literature Corpus work
b80eecf6-03cd-54cb-885c-1c9f73e15a46
DOI
10.64898/2026.05.06.723300
Open publication

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Tryptophan degradation by intestinal Bacteroides induces anti-tumor immunity and limits melanoma growthDOI 10.64898/2026.05.06.723300
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