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Association of gut microbiota and immune gene expression with response to targeted therapy in BRAF mutated melanoma

14 Jul 2025

Abstract excerpt

Gut microbiota has been associated with carcinogenesis and immune regulation. While there is evidence supporting its influence on immunotherapy response in melanoma, its impact on BRAF/MEK-targeted therapy remains unexplored. This study assessed gut microbiota composition and immune-associated genes in melanoma, to generate hypothesis on prognostic and predictive biomarkers for BRAF/MEK inhibitor therapy. This...

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PMID: 40659866
DOI: 10.1038/s41598-025-11054-2

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