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Relating the gut metagenome and metatranscriptome to immunotherapy responses in melanoma patients

9 Oct 2019

Abstract excerpt

BACKGROUND: Recent evidence suggests that immunotherapy efficacy in melanoma is modulated by gut microbiota. Few studies have examined this phenomenon in humans, and none have incorporated metatranscriptomics, important for determining expression of metagenomic functions in the microbial community. METHODS: In melanoma patients undergoing immunotherapy, gut microbiome was characterized in pre-treatment stool...

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PMID: 31597568
DOI: 10.1186/s13073-019-0672-4

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