Article
Circular RNAs: Isolation, characterization and their potential role in diseases.
RNA biology - 2 Dec 2017
Liu Lumei, Wang Jian, Khanabdali Ramin, Kalionis Bill, Tai Xiantao, Xia Shijin
Abstract excerpt
Circular RNA (circRNA) generated by alternative splicing represents a special class of non-coding RNA molecule. CircRNAs are abundant in the eukaryotic cell cytoplasm and have a characteristic organization, timing of action and disease specificity. In contrast to linear RNA, circRNAs are resistant to RNA exonuclease. Consequently, circRNA escapes normal RNA turnover and this improves circRNA stability. CircRNAs...
Topics
- Animals
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genomics
- Humans
- RNA
- RNA Processing, Post-Transcriptional
- RNA, Circular
- Transcription, Genetic