Article

Anti-activin treatment increases T cell infiltration in breast and pancreatic tumours and promotes survival in a SMAD4-null mouse pancreatic cancer model

2025-06-17

Abstract excerpt

Activin A and B share the same downstream signalling pathway (activation of SMAD2/3) as TGF-β and consequently elicit many of the same functional responses as TGF-β, including immune suppression, activation of cancer-associated fibroblasts (CAFs) and extracellular matrix production and remodelling. However, activin’s role in tumourigenesis has been relatively overlooked compared to TGF-β’s. We generated and charac...

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Literature Corpus work: b7dacbdb-8669-5c53-ae50-4d76b37bcea0
DOI: 10.1101/2025.06.13.659133

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