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Article

Loss of Activin Receptor Type 1B Accelerates Development of Intraductal Papillary Mucinous Neoplasms in Mice With Activated KRAS.

Gastroenterology - 1 Jan 2016

Qiu Wanglong, Tang Sophia M, Lee Sohyae, Turk Andrew T, Sireci Anthony N, Qiu Anne, Rose Christian, Xie Chuangao, Kitajewski Jan, Wen Hui-Ju, Crawford Howard C, Sims Peter A, Hruban Ralph H, Remotti Helen E, Su Gloria H

Abstract excerpt

BACKGROUND & AIMS: Activin, a member of the transforming growth factor-β (TGFB) family, might be involved in pancreatic tumorigenesis, similar to other members of the TGFB family. Human pancreatic ductal adenocarcinomas contain somatic mutations in the activin A receptor type IB (ACVR1B) gene, indicating that ACVR1B could be a suppressor of pancreatic tumorigenesis. METHODS: We disrupted Acvr1b specifically in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26408346
DOI: 10.1053/j.gastro.2015.09.013
PMCID: PMC4860725

Genes

KRAS
NOTCH4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Loss of Activin Receptor Type 1B Accelerates Development of Intraductal Papillary Mucinous Neoplasms in Mice With Activated KRAS.PMID 26408346Read ↗

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