Back to search

Article

The <i>Vibrio cholerae</i> MARTX toxin simultaneously induces actin collapse while silencing the inflammatory response to cytoskeletal damage

2019-01-22

Abstract excerpt

<h4> Abstract </h4> Multifunctional autoprocessing repeats-in-toxin (MARTX) toxins are pore-forming toxins that translocate multiple functionally independent effector domains into a target eukaryotic cell. Vibrio cholerae colonizes intestinal epithelial cells (IECs) and utilizes a MARTX toxin with three effector domains — an actin cross-linking domain (ACD), a Rho inactivation domain (RID), and an α/β hydrolase...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b7d74f7a-4532-5ecc-b9b5-71b8e0c2ccd3
DOI
10.1101/526616
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The <i>Vibrio cholerae</i> MARTX toxin simultaneously induces actin collapse while silencing the inflammatory response to cytoskeletal damageDOI 10.1101/526616
The Vibrio cholerae MARTX toxin silences the inflammatory response to cytoskeletal damage before inducing actin cytoskeleton collapse.Semantic proximity
Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites.Semantic proximity
Host-derived CEACAM-laden vesicles engage enterotoxigenic <i>E. coli</i> for elimination and toxin neutralizationSemantic proximity
Glucosyltransferase-dependent and independent effects of <i>Clostridioides difficile</i> toxins during infectionSemantic proximity
Crystal structure of the VgrG1 actin cross-linking domain of the Vibrio cholerae type VI secretion system.Semantic proximity
Shiga toxin suppresses noncanonical inflammasome responses to cytosolic LPSSemantic proximity
MARTX effector cross kingdom activation by Golgi-associated ADP-ribosylation factors.Semantic proximity
The <i>Bordetella</i> effector protein BteA induces host cell death by disruption of calcium homeostasisSemantic proximity
Bacterial Modulation of Intestinal Motility through Macrophage RedistributionSemantic proximity
Presence of WH2 like domain in VgrG-1 toxin of <i>Vibrio cholerae</i> reveals the molecular mechanism of actin cross-linkingSemantic proximity
<i>In Vivo</i> Dual RNA-Seq uncovers key toxin-like effectors of epithelial barrier disruption and tissue colonization by an extracellular bacterial pathogenSemantic proximity
<i>Vibrio campbellii</i> encodes a distinct set of type III secretion system effectors that mediate cytotoxicity in eukaryotic host modelsSemantic proximity
Select a neighboring publication to make it the new centre.