Article

Presence of WH2 like domain in VgrG-1 toxin of <i>Vibrio cholerae</i> reveals the molecular mechanism of actin cross-linking

2017-11-29

Abstract excerpt

Type VI secretion systems (T6SS) plays a crucial role in Vibrio cholerae mediated pathogenicity and predation. Tip of T6SS is homologous to gp27/gp5 complex or tail spike of T4 bacteriophage. VgrG-1 of V. cholerae T6SS is unusual among other VgrG because its effector domain is trans-located into the cytosol of eukaryotic cells with an additional actin cross-linking domain (ACD) at its C terminal end. ACD of VgrG...

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Literature Corpus work: 00db8c01-24ff-5fd6-a35a-6138a965d0a3
DOI: 10.1101/226605

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