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<i>In Vivo</i> Dual RNA-Seq uncovers key toxin-like effectors of epithelial barrier disruption and tissue colonization by an extracellular bacterial pathogen

2025-04-04

Abstract excerpt

Disruption of host cell barriers is a fundamental strategy enabling pathogens to establish a paracellular infection. Using dual RNA-Seq, we determined the in vivo host-pathogen transcriptomic landscape upon infection by the extracellular pathogen Leptospira interrogans and uncovered a novel mechanism of cell-cell junction disruption. We demonstrated that, upon infection, an increase in intracellular calcium trig...

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Literature Corpus work
e8e732d3-c7c3-546f-9130-5cb0875a9efa
DOI
10.1101/2025.04.04.647190
Open publication

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