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Article

Crystal structure of the VgrG1 actin cross-linking domain of the Vibrio cholerae type VI secretion system.

The Journal of biological chemistry - 2 Nov 2012

Durand Eric, Derrez Estelle, Audoly Gilles, Spinelli Silvia, Ortiz-Lombardia Miguel, Raoult Didier, Cascales Eric, Cambillau Christian

Abstract excerpt

Vibrio cholerae is the cause of the diarrheal disease cholera. V. cholerae produces RtxA, a large toxin of the MARTX family, which is targeted to the host cell cytosol, where its actin cross-linking domain (ACD) cross-links G-actin, leading to F-actin depolymerization, cytoskeleton rearrangements, and cell rounding. These effects on the cytoskeleton prevent phagocytosis and bacterial engulfment by macrophages,...

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Identifiers

PMID: 22898822
DOI: 10.1074/jbc.M112.390153
PMCID: PMC3488088

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ACD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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