Article

Synuclein Aggregation: Critical Role of Water in Entropy-Driven, Temperature-Responsive Aggregations of Macromolecules and Cells

2025-06-29

Abstract excerpt

The change from monomeric α-synuclein to aggregated forms plays a fundamental role in the initiation of Parkinson’s diseases that include its genetic subtypes. The biophysics of the homo-aggregation of whole cells (erythrocyte rouleaux) shares many features of the homo-aggregation of macromolecules such as α-synuclein. Evidence from both reveals that the aggregation pressure is determined as much by concentrations...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b7ce4a8c-16e8-58ba-abec-f5eae3d975b3
DOI: 10.32388/9acjg4

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Synuclein Aggregation: Critical Role of Water in Entropy-Driven, Temperature-Responsive Aggregations of Macromolecules and CellsDOI 10.32388/9acjg4Read

Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities.Semantic proximity Read

Hydration Thermodynamics of Familial Parkinson's Disease-Linked Mutants of α-Synuclein.Semantic proximity Read

WT and A53T α-Synuclein Systems: Melting Diagram and Its New Interpretation.Semantic proximity Read

The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel β-sheet α-synuclein aggregatesSemantic proximity Read

Differentially heterogeneous hydration environment of the familial mutants of α-synuclein.Semantic proximity Read

Kinetic control in amyloid polymorphism: Different agitation and solution conditions promote distinct amyloid polymorphs of alpha-synucleinSemantic proximity Read

Divergent effects of pathological α-synuclein truncations and mutations on phase separationSemantic proximity Read

Combined Effects of Mutation and Ionic Strength on α-Synuclein Reveal Generic Features of Aggregation-Prone Monomeric States.Semantic proximity Read

Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study.Semantic proximity Read

High-Pressure-Driven Reversible Dissociation of α-Synuclein Fibrils Reveals Structural Hierarchy.Semantic proximity Read

Divergent effects of pathological α-synuclein truncations and mutations on phase separation.Semantic proximity Read

Protein-Protein Connections-Oligomer, Amyloid and Protein Complex-By Wide Line 1H NMR.Semantic proximity Read