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Article

WT and A53T α-Synuclein Systems: Melting Diagram and Its New Interpretation.

International journal of molecular sciences - 3 Jun 2020

Bokor Mónika, Tantos Ágnes, Tompa Péter, Han Kyou-Hoon, Tompa Kálmán

Abstract excerpt

The potential barriers governing the motions of α-synuclein (αS) variants' hydration water, especially energetics of them, is in the focus of the work. The thermodynamical approach yielded essential information about distributions and heights of the potential barriers. The proteins' structural disorder was measured by ratios of heterogeneous water-binding interfaces. They showed the αS monomers, oligomers and...

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PMID: 32503167
DOI: 10.3390/ijms21113997
PMCID: PMC7312601

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