Article

The extent of protein hydration dictates the preference for heterogeneous or homogeneous nucleation generating either parallel or antiparallel β-sheet α-synuclein aggregates

2020-09-29

Abstract excerpt

α-Synuclein amyloid self-assembly is the hallmark of a number of neurodegenerative disorders, including Parkinson’s disease, although there is still very limited understanding about the factors and mechanisms that trigger this process. Primary nucleation has been observed to be initiated in vitro at hydrophobic/hydrophilic interfaces by heterogeneous nucleation generating parallel β-sheet aggregates, although no...

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Literature Corpus work: ff51444c-a7cf-5ad3-b8a4-94e4b7d82659
DOI: 10.1101/2020.09.28.315325

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