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Article

Differentially heterogeneous hydration environment of the familial mutants of α-synuclein.

The Journal of chemical physics - 21 Oct 2024

Aggarwal Leena, Karmakar Sayan, Biswas Parbati

Abstract excerpt

The behavior of hydration water around familial Parkinson's disease linked mutants of α-synuclein may be linked to the early-onset of Parkinson's disease. For the first time, this study compares the local structure and dynamics of hydration water around different segments of some of the natural mutants of α-synuclein, i.e., E46K, G51D, A30P, and A53E, with that of the wild-type protein through explicit water MD...

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PMID: 39412059
DOI: 10.1063/5.0230853

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