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Article

Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study.

The Journal of biological chemistry - 21 May 2004

Nuscher Brigitte, Kamp Frits, Mehnert Thomas, Odoy Sabine, Haass Christian, Kahle Philipp J, Beyer Klaus

Abstract excerpt

A number of neurodegenerative disorders, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, are characterized by the intracellular deposition of fibrillar aggregates that contain a high proportion of alpha-synuclein (alphaS). The interaction with the membrane-water interface strongly modulates folding and aggregation of the protein. The present study investigates the lipid...

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PMID: 15028717
DOI: 10.1074/jbc.M401076200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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