Article

Loss of nuclear envelope phosphatase CTDNEP1 drives aggressive medulloblastoma by triggering MYC amplification and genomic instability

2021-04-23

Abstract excerpt

<title>Abstract</title> <p>MYC-driven medulloblastomas are highly aggressive childhood brain tumors, however, the genetic events triggering MYC amplification and malignant transformation remain elusive. Here we report that mutations in CTDNEP1, a CTD nuclear-envelope-phosphatase, are the most significantly enriched recurrent alterations in MYC-driven medulloblastomas, and define high-risk subsets with poorer prog...

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Literature Corpus work: 1354b8d1-95ab-51c1-bb44-1aec53b423c4
DOI: 10.21203/rs.3.rs-421098/v1

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