Gene coexpression networks reveal novel molecular endotypes in alpha-1 antitrypsin deficiency.

doi:10.1136/thoraxjnl-2019-214301

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Article

Gene coexpression networks reveal novel molecular endotypes in alpha-1 antitrypsin deficiency.

Thorax - 1 Feb 2021

Chu Jen-Hwa, Zang Wenlan, Vukmirovic Milica, Yan Xiting, Adams Taylor, DeIuliis Giuseppe, Hu Buqu, Mihaljinec Antun, Schupp Jonas C, Becich Michael J, Hochheiser Harry, Gibson Kevin F, Chen Edward S, Morris Alison, Leader Joseph K, Wisniewski Stephen R, Zhang Yingze, Sciurba Frank C, Collman Ronald G, Sandhaus Robert, Herzog Erica L, Patterson Karen C, Sauler Maor, Strange Charlie, Kaminski Naftali

Abstract excerpt

BACKGROUND: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition that causes early onset pulmonary emphysema and airways obstruction. The complete mechanisms via which AATD causes lung disease are not fully understood. To improve our understanding of the pathogenesis of AATD, we investigated gene expression profiles of bronchoalveolar lavage (BAL) and peripheral blood mononuclear cells (PBMCs) in AATD...

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PMID: 33303696
DOI: 10.1136/thoraxjnl-2019-214301
PMCID: PMC10794043

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