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Article

Quantification of biological network perturbations for mechanistic insight and diagnostics using two-layer causal models.

BMC bioinformatics - 11 Jul 2014

Martin Florian, Sewer Alain, Talikka Marja, Xiang Yang, Hoeng Julia, Peitsch Manuel C

Abstract excerpt

BACKGROUND: High-throughput measurement technologies such as microarrays provide complex datasets reflecting mechanisms perturbed in an experiment, typically a treatment vs. control design. Analysis of these information rich data can be guided based on a priori knowledge, such as networks or set of related proteins or genes. Among those, cause-and-effect network models are becoming increasingly popular and more...

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Identifiers

PMID: 25015298
DOI: 10.1186/1471-2105-15-238
PMCID: PMC4227138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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