Article

Network perturbation analysis of gene transcriptional profiles reveals protein targets and mechanism of action of drugs and influenza A viral infection

2017-08-11

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide transcriptional profiling provides a global view of cellular state and how this state changes under different treatments (e.g. drugs) or conditions (e.g. healthy and diseased). Here, we present ProTINA (Protein Target Inference by Network Analysis), a network perturbation analysis method for inferring protein targets of compounds from gene transcriptional profiles. ProTINA uses a dyn...

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Literature Corpus work: c91a1fe6-7c63-5019-8b6e-dda636c59321
DOI: 10.1101/175364

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