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Article

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.

Immunity - 21 Jun 2016

Lassen Kara G, McKenzie Craig I, Mari Muriel, Murano Tatsuro, Begun Jakob, Baxt Leigh A, Goel Gautam, Villablanca Eduardo J, Kuo Szu-Yu, Huang Hailiang, Macia Laurence, Bhan Atul K, Batten Marcel, Daly Mark J, Reggiori Fulvio, Mackay Charles R, Xavier Ramnik J

Abstract excerpt

Although numerous polymorphisms have been associated with inflammatory bowel disease (IBD), identifying the function of these genetic factors has proved challenging. Here we identified a role for nine genes in IBD susceptibility loci in antibacterial autophagy and characterized a role for one of these genes, GPR65, in maintaining lysosome function. Mice lacking Gpr65, a proton-sensing G protein-coupled receptor,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27287411
DOI: 10.1016/j.immuni.2016.05.007
PMCID: PMC4936415

Genes

GPR65

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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