Article

Lineage-dependence of the neuroblastoma surfaceome defines tumor cell state-dependent and independent immunotherapeutic targets

2024-07-02

Abstract excerpt

<h4>Background</h4> Neuroblastoma is a heterogeneous disease with adrenergic (ADRN)- and therapy resistant mesenchymal (MES)-like cells driven by distinct transcription factor networks. Here, we investigate the expression of immunotherapeutic targets in each neuroblastoma subtype and propose pan-neuroblastoma and cell state specific targetable cell-surface proteins. <h4>Methods</h4> We characterized cell lines,...

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Literature Corpus work: b78d916a-82c8-56ec-af37-cbdc61654e92
DOI: 10.1101/2024.06.27.600865

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