Article

Clinically-relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance

2022-04-02

Abstract excerpt

<h4>ABSTRACT</h4> Chemotherapy resistance and relapses are common in high-risk neuroblastoma (NB), an aggressive pediatric solid tumor of the sympathetic nervous system. Here, we developed a clinically-relevant in vivo treatment protocol mimicking the first line five-chemotherapy treatment regimen of high-risk NB and applied this protocol to mice with MYCN -amplified NB patient-derived xenografts (PDXs). Genomic...

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Literature Corpus work: e7fadc96-0b74-5a18-ae0c-93ccf6c77842
DOI: 10.1101/2022.04.01.486670

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